Paying for

If your healthcare provider determines that Afrezza® is right for you, he or she will write you a prescription. Be sure to work with your pharmacy to help determine your insurance coverage and what your out-of-pocket costs will be for Afrezza®.

Explore Your Options

  • Your actual out-of-pocket cost will vary, depending on your specific insurance plan.
  • Nationally, over 70% of patients with commercial insurance (e.g., self-purchased or through an employer) have access to Afrezza® and many patients with Medicare insurance have access as well, depending on the state and plan type.
  • MannKind offers several options to help you with the cost of Afrezza®, depending on the type of insurance coverage you have.

Did you know?

Most patients
do not pay the
list price for Afrezza®?

Please select from the options below that best describes your health coverage:

With the Afrezza® Savings Card, eligible commercially insured patients may pay as little as $15 per month.*

If you have commercial insurance and your health plan does not cover Afrezza® or requires a prior authorization from your insurance plan, you may still be able to get Afrezza® from your pharmacy for $15 per month while coverage is being pursued.* Please see for eligibility requirements and program terms and conditions.

While at your healthcare provider’s office, download your savings card so they can include the BIN, PCN, and Group Number when sending your prescription to your pharmacy.

If you have Medicare Part D coverage and are eligible for Part D Low Income Subsidy, you may pay $8.95 or less per month for your prescription. If you are unsure whether you qualify for Low Income Subsidy and would like more information, please visit Medicare’s Extra Help site. If you don’t qualify for Low Income Subsidy, your out-of-pocket costs will vary, depending on which phase of the Medicare Part D Insurance benefit you are currently in.

If you do not have prescription drug coverage, cannot afford your medication, or your insurance denies because your insurance doesn’t cover Afrezza®, options may exist to help offset the cost.

MannKind also offers a direct purchase program. You may be eligible to get Afrezza® for as little as $99/month. For more information, and to see full terms and conditions, click here.

Navigate the insurance and approval process for Afrezza® with this guide.

Still have questions? Our Patient Support Guides can help you navigate insurance coverage and explain how to use your Afrezza® Savings Card.





Filling Your Prescription

Afrezza® is available at your local neighborhood retail pharmacy, as well as specialty or mail order pharmacies, which often handle medicines that need extra care and ship them directly to your address.

Before you leave your healthcare provider’s office, confirm the name and phone number of the pharmacy that your healthcare provider sent your prescription, and save it to your phone so you can expect the pharmacy’s call.

If your pharmacy doesn’t have Afrezza® in stock, be prepared to give the pharmacy at least 48 hours to fill your order as some locations may need to have Afrezza® shipped to them.

You will pay for your prescription upon pick up or delivery. Be sure to bring your insurance information and download or print your Afrezza® Savings Card.

If your pharmacy experiences any issues ordering Afrezza®, or using the Afrezza® Savings Card, call AfrezzaAssist℠ at 1-844-323-7399, MONDAY–FRIDAY, 8 AM–8 PM ET

*What you pay for Afrezza® will depend on your insurance plan. Each plan has different preferred drug lists and out-of-pocket amounts, and most include an annual deductible. If you haven’t met your deductible, you’ll see higher prices until the deductible is met, then your out-of-pocket cost will likely drop. This offer is available for patients with commercial drug insurance coverage. It is not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Maximum savings limit applies; patient out-of-pocket expense may vary. If the patient’s health plan does not cover Afrezza® or requires a prior authorization, the patient can qualify for the Bridge Buy-Down offer and receive Afrezza® for $15 while pursuing approval from their health plan. No purchase necessary. See full Program Terms, Conditions, and Eligibility Criteria. If approved by the patient’s health plan to take Afrezza®, a patient will pay as little as $15 per month. This applies to patient out-of-pocket costs, including deductible, co-insurance, and copayments for Afrezza®. See full Program Terms, Conditions, and Eligibility Criteria.


  1. Afrezza® (insulin human) Inhalation Powder Prescribing Information. MannKind Corporation.
  2. Q1 Medicare. 2019 Medicare Part D Outlook. Accessed on July 23, 2019.
  3. Social Security Administration (SSA). Extra Help with Medicare Prescription Drug Plan Costs. Accessed on July 23, 2019.


Important Safety Information for Afrezza® (insulin human) Inhalation Powder

Afrezza® can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza® if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza®, your healthcare provider will give you a breathing test to check how your lungs are working.

Important Safety Information

What is the most important information I should know about Afrezza®?

Afrezza® can cause serious side effects, including:
Sudden lung problems (bronchospasms). Do not use Afrezza® if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza®, your healthcare provider will give you a breathing test to check how your lungs are working.

  • Afrezza® is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.
  • Afrezza® is not for use in place of long-acting insulin. Afrezza® must be used with long-acting insulin in people who have type 1 diabetes mellitus.
  • Afrezza® is not for use to treat diabetic ketoacidosis.
  • It is not known if Afrezza® is safe and effective for use in people who smoke. Afrezza® is not for use in people who smoke or have recently stopped smoking (less than 6 months).
  • It is not known if Afrezza® is safe and effective in children under 18 years of age.

Do not use Afrezza® if you:

  • Have chronic lung problems such as asthma or COPD.
  • Are allergic to regular human insulin or any of the ingredients in Afrezza®. See the end of this Medication Guide for a complete list of ingredients in Afrezza®.

Before using Afrezza®, tell your healthcare provider about all your medical conditions, including if you:

  • Have lung problems such as asthma or COPD
  • Have or have had lung cancer
  • Are using any inhaled medications
  • Smoke or have recently stopped smoking
  • Have kidney or liver problems
  • Are pregnant, planning to become pregnant, or are breastfeeding. Afrezza® may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.

Before you start using Afrezza®, talk to your healthcare provider about low blood sugar and how to manage it.

  • Read the detailed Instructions for Use that comes with your Afrezza®.
  • Take Afrezza® exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza® to use and when to use it.
  • Know the strength of Afrezza® you use. Do not change the amount of Afrezza® you use unless your healthcare provider tells you to.
  • Take Afrezza® at the beginning of your meal.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check your blood sugar levels.
  • Keep Afrezza® and all medicines out of the reach of children.

  • Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take.

While using Afrezza® do not:

  • Drive or operate heavy machinery, until you know how Afrezza® affects you.
  • Drink alcohol or use over-the-counter medicines that contain alcohol.
  • Smoke.

Afrezza® may cause serious side effects that can lead to death, including:

See “What is the most important information I should know about Afrezza®?” at the top of this page.

  • Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:

    • Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
  • Decreased lung function. Your healthcare provider should check how your lungs are working before you start using Afrezza®, 6 months after you start using it and yearly after that.
  • Lung cancer. In studies of Afrezza® in people with diabetes, lung cancer occurred in a few more people who were taking Afrezza® than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to Afrezza®. If you have lung cancer, you and your healthcare provider should decide if you should use Afrezza®.
  • Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your Afrezza® dose or how often you check your blood sugar may need to be changed.
  • Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction:

    • A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • Low potassium in your blood (hypokalemia).
  • Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with Afrezza® may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with Afrezza®. Your healthcare provider should monitor you closely while you are taking TZDs with Afrezza®. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:

    • Shortness of breath, swelling of your ankles or feet, sudden weight gain.

Treatment with TZDs and Afrezza® may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have:

• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of Afrezza® include:

  • Low blood sugar (hypoglycemia), cough, sore throat

These are not all the possible side effects of Afrezza®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).

Active ingredient: human insulin

Inactive ingredients: fumaryl diketopiperazine, polysorbate 80

General information about the safe and effective use of Afrezza®.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza® for a condition for which it was not prescribed. Do not give Afrezza® to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Afrezza®. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza® that is written for health professionals.

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