If diet, exercise, and your current diabetes medications are no longer giving you the blood sugar control you need, ask your healthcare provider about Afrezza. Afrezza may be able to help.
Inhale Afrezza at the beginning of your meal to bring down blood sugars caused by eating. After you inhale Afrezza, the insulin passes quickly through your lungs and into your bloodstream (in less than one minute).1 This allows insulin to get into your blood quickly and work on reducing blood sugars within about 12 minutes.2 This rapid action allows you to take Afrezza when you are ready to eat and not worry about timing your mealtime insulin in advance of your meals.
Afrezza is designed to be in your body for approximately 1.5 - 4 hours,** depending on your dose.2 Once Afrezza leaves your system it doesn't continue to lower your blood sugar. This helps you time your insulin therapy to your insulin need.
** For the 4 and 12 unit cartridges respectively.
Research shows that the better you get your blood sugar in control, the lower your risk can be for long term complications such as eye, heart, kidney, and nerve damage.3
By keeping your blood sugar levels in a healthy range through food choices, physical activity, and proper medications, you can avoid long-term diabetes complications.3
These complications can develop over many years and they all relate to how blood sugar (also called blood glucose) levels affect the blood vessels. Over time, high amounts of sugars in your blood can damage the body's blood vessels, both tiny (microvascular) and large (macrovascular).4
How will switching to inhaled insulin change your day?
Afrezza is not for use in place of long-acting insulin. Afrezza must be used with long-acting insulin in people who have type 1 diabetes.
Afrezza is insulin used at the beginning of a meal with an oral inhaler and one or more single-use cartridges. Afrezza cartridges comes in three doses: 4, 8 and 12-unit cartridges.
Your healthcare provider will give you direction on how to take Afrezza and help you find the right dose per meal for you.
If you are switching from an injectable mealtime insulin to Afrezza, it is important to remember that Afrezza insulin units are different than injected insulin units. If you are not seeing the results you expect with Afrezza, contact your healthcare provider about changing your dose.
If you require more than 12 units at a time, you can use multiple cartridges.
* Assumes 1 needle per meal, 3 meals per day for 365 days, rounded down. ** For the 4 and 12 unit cartridges respectively.
 Data on file
 Afrezza® (insulin human) Inhalation Powder Prescribing Information. MannKind Corporation
 American Diabetes Association. Standards of Medical Care in Diabetes 2018. Diabetes Care 2018 Jan; vol41 (Supplement 1): S1 -S2. doi: 10.2337/dc18-S004.
 Nathan DM, for the DCC/EDIC Research Group. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview. Diabetes Care. 2014;37(1):9-16. doi:10.2337/dc13-2112.
Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
What is the most important information I should know about Afrezza? Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD).
Afrezza can cause serious side effects, including:
Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
Do not use Afrezza if you:
Before using Afrezza, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.
Before you start using Afrezza, talk to your healthcare provider about low blood sugar and how to manage it.
While using Afrezza do not:
Afrezza may cause serious side effects that can lead to death, including:
See “What is the most important information I should know about Afrezza?” at the top of this page.
Treatment with TZDs and Afrezza may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.
Get emergency medical help if you have:
• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
The most common side effects of Afrezza include:
These are not all the possible side effects of Afrezza. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).
Active ingredient: human insulin
Inactive ingredients: fumaryl diketopiperazine, polysorbate 80
General information about the safe and effective use of Afrezza.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza for a condition for which it was not prescribed. Do not give Afrezza to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about Afrezza. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza that is written for health professionals. For more information, go to www.afrezza.com or call MannKind Corp. 1-877-323-8505.