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Afrezza is an FDA-approved medication for adults with type 1 or type 2 diabetes. Talk to your healthcare provider to see if Afrezza is right for you. 


MannKind Cares®

MannKind is committed to helping people gain access to Afrezza.

MannKind Cares supports people with diabetes and caregivers who have questions about Afrezza. We understand the challenges people may face with the healthcare system and are here to help. MannKind Cares provides support services to help answer your questions related to insurance coverage, prescription cost, and product use.

If your doctor recommends Afrezza for you, ask your physician about enrolling you in MannKind Cares.  We will work with your insurance provider to check whether Afrezza is covered and provide support to get your prescription filled.  Please contact us if you have questions. 

Questions to ask your doctor

Use these questions to start the conversation with your healthcare provider. 

  • How does Afrezza work?
  • How is Afrezza different from other fast-acting insulin?
  • How can Afrezza help me manage my diabetes?
  • Will Afrezza replace my current long-acting insulin?
  • How will I know how much Afrezza to use?
  • Is Afrezza right for me?
Read more from our FAQs
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What is an FEV1 Test?

The FEV1 test is a simple breathing test your healthcare provider can perform in their office. This test is done before starting Afrezza to establish a baseline reading. After the baseline has been established, your healthcare provider may test at 6 months and once a year after that. The test measures how an individual inhales or exhales volumes of air and is used to monitor your lung function over time.

Find a doctor

Looking for a doctor who has experience prescribing Afrezza? Do you have questions about Afrezza and managing your diabetes? Search for a doctor by zip code or state using the drop-down menu below.* Our list is constantly growing, so check back regularly for updates.

Doctor Locator Tool

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*This physician locator tool is provided by MannKind Corp. (“MannKind”) solely to assist you in locating a physician who has experience with Afrezza. This physician locator tool should not be construed in any way as an endorsement or recommendation by MannKind as to the qualifications of any physicians listed in this tool or the quality of medical care they can provide. MannKind makes no guarantees that using a physician from this list will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. MannKind recommends that you meet and discuss the benefits and risks of treatments and the procedure to administer the product with the potential physician.

MannKind and its affiliates hereby disclaim any and all liability arising from your use of and/or reliance on the information contained in this physician locator tool.

Afrezza Savings Card 2018


With the Afrezza Patient Savings Card, you may pay as little as $15 for each inhaled insulin prescription depending on your insurance coverage. Terms and conditions apply.**

**Offer is not valid for patients if their prescriptions are paid in part or in full by any state or federally funded programs, including, but not limited to, Medicare or Medicaid, Medigap, VA, DOD or TRICARE. Offer is not valid, where prohibited by law. MannKind Corporation reserves the right to rescind, revoke, or amend this offer without notice. Maximum benefit may vary based on NDC for the duration of the program. Eligibility criteria: Only patients who reside in the United States, Puerto Rico, Guam or the U.S. Virgin Islands can participate in this program. If you have any questions about this program, please call 855-262-5296, or if you have questions about Afrezza, talk to your healthcare professional.

Important Safety Information for Afrezza (insulin human) Inhalation Powder

Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.


What is the most important information I should know about Afrezza?

Afrezza can cause serious side effects, including:

Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.

  • Afrezza is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus. 
  • Afrezza is not for use in place of long-acting insulin. Afrezza must be used with long-acting insulin in people who have type 1 diabetes mellitus. 
  • Afrezza is not for use to treat diabetic ketoacidosis. 
  • It is not known if Afrezza is safe and effective for use in people who smoke. Afrezza is not for use in people who smoke or have recently stopped smoking (less than 6 months). 
  • It is not known if Afrezza is safe and effective in children under 18 years of age.

Do not use Afrezza if you:

  • Have chronic lung problems such as asthma or COPD.
  • Are allergic to regular human insulin or any of the ingredients in Afrezza. See the end of this Medication Guide for a complete list of ingredients in Afrezza. 

Before using Afrezza, tell your healthcare provider about all your medical conditions, including if you:

  • Have lung problems such as asthma or COPD
  • Have or have had lung cancer
  • Are using any inhaled medications
  • Smoke or have recently stopped smoking
  • Have kidney or liver problems
  • Are pregnant, planning to become pregnant, or are breastfeeding. Afrezza may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.

Before you start using Afrezza, talk to your healthcare provider about low blood sugar and how to manage it.

  • Read the detailed Instructions for Use that comes with your Afrezza.
  • Take Afrezza exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza to use and when to use it.
  • Know the strength of Afrezza you use. Do not change the amount of Afrezza you use unless your healthcare provider tells you to.
  • Take Afrezza at the beginning of your meal.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check your blood sugar levels.
  • Keep Afrezza and all medicines out of the reach of children.
  • Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take. 

While using Afrezza do not:

  • Drive or operate heavy machinery, until you know how Afrezza affects you.
  • Drink alcohol or use over-the-counter medicines that contain alcohol.
  • Smoke.

Afrezza may cause serious side effects that can lead to death, including:

See “What is the most important information I should know about Afrezza?” at the top of this page.

  • Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:
    • Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
  • Decreased lung function. Your healthcare provider should check how your lungs are working before you start using Afrezza, 6 months after you start using it and yearly after that.
  • Lung cancer. In studies of Afrezza in people with diabetes, lung cancer occurred in a few more people who were taking Afrezza than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to Afrezza. If you have lung cancer, you and your healthcare provider should decide if you should use Afrezza.
  • Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your Afrezza dose or how often you check your blood sugar may need to be changed.
  • Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction:
    • A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • Low potassium in your blood (hypokalemia).
  • Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with Afrezza may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with Afrezza. Your healthcare provider should monitor you closely while you are taking TZDs with Afrezza. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:
    • Shortness of breath, swelling of your ankles or feet, sudden weight gain.

Treatment with TZDs and Afrezza may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have:

• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of Afrezza include:

  • Low blood sugar (hypoglycemia), cough, sore throat

These are not all the possible side effects of Afrezza. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).

Active ingredient: human insulin

Inactive ingredients: fumaryl diketopiperazine, polysorbate 80

General information about the safe and effective use of Afrezza.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza for a condition for which it was not prescribed. Do not give Afrezza to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Afrezza. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza that is written for health professionals. For more information, go to or call MannKind Corp. 1-877-323-8505.